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Brain Restoration

Are you experiencing anxiety, depression, memory challenges? Do you want to prevent Alzheimer’s/Dementia, Parkinson’s, Multiple Sclerosis? Are you suffering from the lingering effects of a head injury? As we age, there is a decline in energy metabolism in the brain. One large contributing factor is lower levels of NAD in the system. NAD levels decline with age.

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Alzheimer’s Disease

Low NAD levels are associated with cell death and cognitive impairment. Studies in animal models of aging and Alzheimer’s Disease have shown that restoring youthful NAD levels improves cognitive function significantly.

Parkinson’s Disease

Parkinson’s Disease occurs from dopaminergic neuronal death in the brain from Lewey Bodies or protein clumps that build up in the brain. The co-factor NAD serves a vital role in dopaminergic neuronal replenishment, where NAD depletion has been associated with the onset of neurodegenerative disease such as PD. Additionally, in a previous case study in a PD patient, an Intravenous (IV) NAD administration protocol showed a rapid and sustained alleviation of PD-related symptoms.

Multiple Sclerosis

Approved disease modifying therapies for MS are not effective. Evidence of mitochondrial damage in MS has led to the hypothesis that neurodegeneration results from energy depletion in neurons. This, in turn, led to studies designed to understand the changes occurring in mitochondria to identify potential therapeutic targets. Depletion of NAD has been identified as an important mediator in MS expression.

Traumatic Brain Injury


A key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction. Our findings support that succinate induced NAD may support brain energy metabolism in select TBI patients suffering from mitochondrial dysfunction.

Through NAD treatment, our goal is to help you address the root causes of your symptoms for optimal, long-term healing. NAD IV’s are used to both potentially prevent and reverse these conditions. Our Brain Restoration NAD may be the path toward helping you begin to recover and feel like yourself again.

References

  1. Wang X, He H-J, Xiong X, Zhou S et al.NAD in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo. Cell Dev. Biol. 9:668491. Doi:10.3389/fcell.2021.668491
  2. Geriatrics 2024. Highlighted Grant. Elevating NAD levels in Brain May Improve Aging. Prevent Alzheimer’s Disease (Research Updates)
  3. Rutherford L, et al., 2020. Intravenous Administration of Nicotinamide Adenine Di- nucleotide Alleviates Tremors Associated with Parkinson’s Disease: A Case Report6:047 DOI: 10.24966/GGM-8662/100047 HSOA Journal of Gerontology & Geriatric Medicine
  4. Wang, J., Runxuan, Sun, Runxuan., Xia, Linhan et al. Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo. Brain Sci. 2022, 12, 1699. https://doi.org/10.3390/brainsci12121699
  5. Vamshi K.C. Nimmagadda, Tapas K. Makar,  Krish Chandrasekaran, et al. SIRT1 and NAD + precursors: Therapeutic targets in multiple sclerosis a review. Journal of Neuroimmunology, Vol 304, 15 March 2017, 29-35
  6. Matthew G. Stovell, Marius O. Mada, Adel Helmy, et al. The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury. Scientific Reports | (2018) 8:11140 | DOI:10.1038/s41598-018-29255-3

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